Pangobright virus.Scientists Find Strains of Coronaviruses Closely Related to COVID-19 virus in Pangolins

 

Pangobright virus.Coronavirus: From bats to pangolins, how do viruses reach us?

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Calls to end illegal wildlife trade.Pangolins May Have Passed Coronavirus From Bats to Humans

 

Mar 27,  · But some theories suggest that pangolins may be the source of the novel coronavirus. The idea is that pangolins carrying the virus, SARS-CoV-2, came into contact with humans. The virus . Apr 11,  · More Evidence Suggests Pangolins May Have Passed Coronavirus From Bats to Humans Mystery of zoonotic transmission. Since January , the current consensus among the scientific community is that Snakes make unlikely host. The early claim that snakes transmitted SARS-CoV-2 was based on an Estimated Reading Time: 6 mins. Feb 10,  · T he pangolin is known around the world for not only being Prince William ‘s favourite animal but also as one of the most critically endangered species on .

 

Pangobright virus.Study shows pangolins may have passed new coronavirus from bats to humans

Feb 10,  · T he pangolin is known around the world for not only being Prince William ‘s favourite animal but also as one of the most critically endangered species on . Mar 26,  · A trafficked pangolin in Kuala Lumpur: The animal is a suspect in the outbreak Smuggled pangolins have been found to carry viruses closely related to Estimated Reading Time: 2 mins. Pangolins are now confirmed carriers of viruses closely related to SARS-CoV But as with SARS and MERS, bats are the most likely original source. Scientists believe bats’ unique genetic quirks.
 
 
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Coronavirus: Pangolins may have spread the disease to humans

Pangolins , not snakes , may be the missing link for transmission of the new coronavirus from bats to humans. A critical challenge is to determine which animal transmitted the virus to humans.

We are a team of bioinformaticians and we feel it is our responsibility to the global community to investigate the origin of this virus. Based on the research in our lab , we believe that pangolins , as opposed to snakes , may have served as the hosts that transmitted the coronavirus to people and caused the ongoing COVID pandemic.

The pangolin, also known as a scaly anteater, is the only known mammal with scales and is found in Asia and Africa. It was also found to have been transmitted from bats to an intermediate host — the masked palm civet — which subsequently infected humans.

The identity of the intermediate host of SARS-CoV-2 is therefore a mystery that many researchers hope to solve, as knowing the intermediate host is very helpful for prevention of further spread of epidemic.

Yet, this conclusion quickly drew skepticism , partly because there exists no previous evidence that coronaviruses can jump from a cold-blooded animal, such as snakes, to human beings. For both viruses and animal cells to function, genetic sequences RNA or DNA must be translated into proteins, which then carry out many tasks of the virus and the cell.

These proteins exist as linked chains of single amino acids; each amino acid in a protein is encoded by a group of three nucleotides, also known as a codon, in the genetic sequence.

Since there are 64 possible different codons but only 20 amino acids, several codons can correspond to the same amino acid; different organisms will have different preference for which codon is used for a given amino acid. The early study hypothesized that for the coronavirus to effectively grow inside an animal cell, the codon usage preferences of the coronavirus should match that of the host cell. That study found that the snakes share the most similar codon usage pattern to SARS-CoV-2, thereby declaring that snakes were the most likely intermediate hosts.

However, their central hypothesis that coronaviruses and their animal hosts share similar codon usage was never verified. Our team at the University of Michigan scrutinized this hypothesis, and performed a more systematic analysis that we published in a recent follow-up study.

To our surprise, we found that the codon usage of a coronavirus is not determined by its hosts. Our follow-up study also found that the genetic sequence of a coronavirus, discovered in lung samples of Malayan pangolins , was highly similar to SARS-CoV There is a particularly strong similarity between the spike proteins of these two viruses. The spike protein, which is on the surface of a coronavirus, is used by the virus to get into an animal cell. Meanwhile, several other research groups have found further experimental evidence of pangolins being infected by coronaviruses highly similar to SARS-CoV While pangolins are now our top suspect as the intermediate host, our study concludes that other potential intermediate hosts should still be considered.

A coronavirus can use more than one kind of animal to infect humans: For example, while civets are best known for transmitting SARS, other animals such as raccoon dogs and ferret badgers are also able to carry SARS.

Similarly, cats and ferrets can also be infected by SARS-CoV-2; it is still unknown whether humans can get infected by the coronavirus residing within these animals. This article is republished from The Conversation , a nonprofit news site dedicated to sharing ideas from academic experts. Snakes could be the original source of the new coronavirus outbreak in China. The new coronavirus emerged from the global wildlife trade — and may be devastating enough to end it. The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

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